methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

Base Information

Chemical Name:methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate
CAS No.:554446-27-4
Molecular Formula:C₂₆H₂₈F₂N₂O₄
Molecular Weight:470.516
Hs Code.:

Synonyms:methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

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Chemical Property of methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

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Technology Process of methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

There total 7 articles about methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 554448-72-5
(2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide

: 67-56-1
methanol

: methyl (2S)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

: 554446-27-4
methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

Guidance literature:: (2RS)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)ethanamide; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 16h;

methanol; In dichloromethane; at 20 ℃;
DOI:10.1021/jm060073e

Reference yield:

: 2-[(2,4-difluoro-benzylidene)-amino]-4-methyl-pentanoic acid methyl ester

: 554446-27-4
methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 24 h / 20 °C

2.1: 2.0 g / H₂; AcOH / Pd/C / ethyl acetate / 2 h

3.1: carbonyldiimidazole / CH₂Cl₂ / 16 h / 20 °C

3.2: 66 percent / CH₂Cl₂ / 20 °C

With hydrogen; acetic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; 1.1: Ugi reaction;
DOI:10.1021/jm060073e

Reference yield:

: 554448-74-7
(2R)-2,3-dihydro-1H-inden-2-yl({[(phenylmethyl)oxy]carbonyl}amino)ethanoic acid

: 554446-27-4
methyl (2R)-(2,4-difluorophenyl)[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]ethanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 24 h / 20 °C

2.1: 2.0 g / H₂; AcOH / Pd/C / ethyl acetate / 2 h

3.1: carbonyldiimidazole / CH₂Cl₂ / 16 h / 20 °C

3.2: 66 percent / CH₂Cl₂ / 20 °C

With hydrogen; acetic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; 1.1: Ugi reaction;
DOI:10.1021/jm060073e