(4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Base Information

Chemical Name:(4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
CAS No.:1624606-85-4
Molecular Formula:C₁₃H₁₄F₅N₃O
Molecular Weight:323.266
Hs Code.:

Synonyms:(4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

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Chemical Property of (4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Chemical Property:

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Technology Process of (4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

There total 8 articles about (4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1624606-84-3
(4S,6S)-4-(2-fluoro-3-methyl-5-nitrophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 96042-30-7
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

: 1624606-85-4
(4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: With acetic acid; In ethanol;

Reference yield:

: (R)-N-((Z)-4-(2,2-dimethylhydrazono)-1,5,5,5-tetrafluoro-2-(2-fluoro-3-methylphenyl)pentan-2-yl)-2-methylpropane-2-sulfinamide

: 1624606-85-4
(4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane; diethyl ether

2: sodium hydrogencarbonate / ethyl acetate

3: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; 1,4-dioxane

4: ethyl acetate

5: potassium nitrate; sodium hydrogencarbonate / water; sulfuric acid

6: acetic acid / ethanol

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; potassium nitrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; sulfuric acid; water; ethyl acetate;

Reference yield:

: 1624606-77-4
2-fluoro-1-(2-fluoro-3-methylphenyl)ethanone

: 1624606-85-4
(4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran; ethyl acetate

2: lithium diisopropyl amide / tetrahydrofuran; ethyl acetate; toluene; n-heptane; ethylbenzene

3: hydrogenchloride / ethyl acetate; water; 1,4-dioxane; diethyl ether

4: sodium hydrogencarbonate / ethyl acetate

5: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; 1,4-dioxane

6: ethyl acetate

7: potassium nitrate; sodium hydrogencarbonate / water; sulfuric acid

8: acetic acid / ethanol

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; potassium nitrate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; n-heptane; ethylbenzene; sulfuric acid; water; ethyl acetate; toluene;