N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Base Information

Chemical Name:N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide
CAS No.:1624606-82-1
Molecular Formula:C₂₀H₁₇F₅N₂O₂
Molecular Weight:412.359
Hs Code.:

Synonyms:N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

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Technology Process of N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

There total 4 articles about N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (R)-2-methyl-N-((2S,4S)-1,5,5,5-tetrafluoro-2-(2-fluoro-3-methylphenyl)-4-hydroxypentan-2-yl)propane-2-sulfinamide

: 532-55-8
Benzoyl isothiocyanate

: 1624606-82-1
N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

Reference yield:

: 1624606-77-4
2-fluoro-1-(2-fluoro-3-methylphenyl)ethanone

: 1624606-82-1
N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; ethyl acetate

2: lithium diisopropyl amide / tetrahydrofuran; ethyl acetate; toluene; n-heptane; ethylbenzene

3: hydrogenchloride / ethyl acetate; water; 1,4-dioxane; diethyl ether

4: sodium hydrogencarbonate / ethyl acetate

5: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; 1,4-dioxane

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; n-heptane; ethylbenzene; water; ethyl acetate; toluene;

Reference yield:

: 59907-12-9
3-bromo-2-fluorotoluene

: 1624606-82-1
N-((4S,6S)-4-(2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / tetrahydrofuran; ethyl acetate

2: tetrahydrofuran; ethyl acetate

3: lithium diisopropyl amide / tetrahydrofuran; ethyl acetate; toluene; n-heptane; ethylbenzene

4: hydrogenchloride / ethyl acetate; water; 1,4-dioxane; diethyl ether

5: sodium hydrogencarbonate / ethyl acetate

6: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; 1,4-dioxane

With hydrogenchloride; n-butyllithium; sodium hydrogencarbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; n-heptane; ethylbenzene; water; ethyl acetate; toluene;