N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

Base Information

Chemical Name:N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide
CAS No.:1624605-15-7
Molecular Formula:C₂₁H₁₉F₇N₄O₂
Molecular Weight:492.396
Hs Code.:

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

Synonyms:N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

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Chemical Property of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

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Technology Process of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

There total 9 articles about N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.69%

: 1386986-16-8
5-difluoromethyl-3-methylpyridine-2-carboxylic acid

: 1624606-85-4
(4S,6S)-4-(5-amino-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 96042-30-7
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

: 1624605-15-7
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

Guidance literature:: In N,N-dimethyl-formamide;

Reference yield:

: (R)-N-((Z)-4-(2,2-dimethylhydrazono)-1,5,5,5-tetrafluoro-2-(2-fluoro-3-methylphenyl)pentan-2-yl)-2-methylpropane-2-sulfinamide

: 1624605-15-7
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane; diethyl ether

2: sodium hydrogencarbonate / ethyl acetate

3: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; 1,4-dioxane

4: ethyl acetate

5: potassium nitrate; sodium hydrogencarbonate / water; sulfuric acid

6: acetic acid / ethanol

7: N,N-dimethyl-formamide

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; potassium nitrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; sulfuric acid; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1624606-77-4
2-fluoro-1-(2-fluoro-3-methylphenyl)ethanone

: 1624605-15-7
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran; ethyl acetate

2: lithium diisopropyl amide / tetrahydrofuran; ethyl acetate; toluene; n-heptane; ethylbenzene

3: hydrogenchloride / ethyl acetate; water; 1,4-dioxane; diethyl ether

4: sodium hydrogencarbonate / ethyl acetate

5: hydrogenchloride; triethylamine / tetrahydrofuran; ethyl acetate; 1,4-dioxane

6: ethyl acetate

7: potassium nitrate; sodium hydrogencarbonate / water; sulfuric acid

8: acetic acid / ethanol

9: N,N-dimethyl-formamide

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; potassium nitrate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; n-heptane; ethylbenzene; sulfuric acid; water; ethyl acetate; N,N-dimethyl-formamide; toluene;