((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester
CAS No.:1476720-95-2
Molecular Formula:C₂₂H₂₉BrN₄O₃
Molecular Weight:477.401
Hs Code.:

Synonyms:((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Suppliers and Price of ((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

There total 11 articles about ((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1476720-93-0
(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1476720-95-2
((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1476720-95-2
((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; sodium hydroxide / water / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In dichloromethane; water;

Reference yield:

: 1118-90-7
L-homoglutamic acid

: 1476720-95-2
((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: water; acetic acid / 3 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 0 - 20 °C / Inert atmosphere

3.1: dmap / acetonitrile / 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

4.2: -78 °C / Inert atmosphere

5.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 40 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / methanol / 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere

8.1: ammonium acetate / toluene / Inert atmosphere; Reflux

9.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; thionyl chloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; ammonium acetate; water; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;