(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

Base Information

Chemical Name:(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine
CAS No.:1476720-93-0
Molecular Formula:C₁₅H₁₈BrN₃
Molecular Weight:320.232
Hs Code.:

Synonyms:(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

Suppliers and Price of (2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

There total 9 articles about (2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1476720-91-8
(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carboxylic acid tert-butyl ester

: 1476720-93-0
(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1118-90-7
L-homoglutamic acid

: 1476720-93-0
(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: water; acetic acid / 3 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 0 - 20 °C / Inert atmosphere

3.1: dmap / acetonitrile / 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

4.2: -78 °C / Inert atmosphere

5.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 40 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / methanol / 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere

8.1: ammonium acetate / toluene / Inert atmosphere; Reflux

9.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; thionyl chloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; ammonium acetate; water; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; acetonitrile;

Reference yield:

: 34622-39-4
(2S)-6-oxopipecolic acid

: 1476720-93-0
(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 0 - 20 °C / Inert atmosphere

2.1: dmap / acetonitrile / 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

4.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 40 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / methanol / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere

7.1: ammonium acetate / toluene / Inert atmosphere; Reflux

8.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; thionyl chloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; ammonium acetate; water; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; acetonitrile;