[(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

Base Information

Chemical Name:[(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester
CAS No.:1476720-97-4
Molecular Formula:C₂₈H₄₁BN₄O₅
Molecular Weight:524.468
Hs Code.:

[(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

Synonyms:[(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

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Chemical Property of [(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

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Technology Process of [(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

There total 12 articles about [(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1476720-95-2
((S)-1-{(2S,5S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-5-methyl-piperidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

: 73183-34-3
bis(pinacol)diborane

: 1476720-97-4
[(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; for 3h; Reflux; Inert atmosphere;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1476720-97-4
[(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; sodium hydroxide / water / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1118-90-7
L-homoglutamic acid

: 1476720-97-4
[(S)-2-methyl-1-((2S,5S)-5-methyl-2-{5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-piperidine-1-carbonyl)-propyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: water; acetic acid / 3 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 0 - 20 °C / Inert atmosphere

3.1: dmap / acetonitrile / 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

4.2: -78 °C / Inert atmosphere

5.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 40 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / methanol / 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere

8.1: ammonium acetate / toluene / Inert atmosphere; Reflux

9.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

11.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With hydrogenchloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; ammonium acetate; water; potassium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;