methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Base Information

Chemical Name:methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate
CAS No.:108713-19-5
Molecular Formula:C₂₅H₂₈N₂O₆S
Molecular Weight:484.573
Hs Code.:

Synonyms:methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

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Chemical Property of methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

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Technology Process of methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

There total 3 articles about methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 67-56-1
methanol

: 108713-16-2
methyl 2-<(benzyloxy)carbonyl>-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>oct-7-ene-6-endo-carboxylate

: 108713-19-5
methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Guidance literature:: With cyclohexa-1,3-diene; trifluoroacetic acid; palladium on activated charcoal; at 25 ℃; for 1h;
DOI:10.1021/jo00390a034

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 108713-19-5
methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium borohydride / 1.) methanol, -78 deg C, 15 min, 2.) methanol, -78 deg C, 15 min

2: 55 percent / xylene / 72 h / 68 - 70 °C

3: 90 percent / cyclohexadiene, trifluoroacetic acid / 10percent Pd/C / 1 h / 25 °C

With sodium tetrahydroborate; cyclohexa-1,3-diene; trifluoroacetic acid; palladium on activated charcoal; In xylene;
DOI:10.1021/jo00390a034

Reference yield:

: 108713-15-1
1-<(benzyloxy)carbonyl>-4-methoxy-1,2-dihydropyridine

: 108713-19-5
methyl 8,8-dimethoxy-6-exo-<1-(phenylsulfonyl)indol-2-yl>-8-methoxy-2-azabicyclo<2.2.2>octane-6-endo-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / xylene / 72 h / 68 - 70 °C

2: 90 percent / cyclohexadiene, trifluoroacetic acid / 10percent Pd/C / 1 h / 25 °C

With cyclohexa-1,3-diene; trifluoroacetic acid; palladium on activated charcoal; In xylene;
DOI:10.1021/jo00390a034