3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester

Base Information

• Chemical Name: 3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester
• CAS No.: 905858-82-4
• Molecular Formula: C₁₈H₂₃N₃O₈
• Molecular Weight: 409.396

Synonyms:3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester

Chemical Property of 3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester

There total 2 articles about 3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-nitro-1,3-benzenedicarbonylchloride (13438-30-7) + ethyl β-alaninate hydrochloride (4244-84-2) → 3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester (905858-82-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm0600949

Reference yield:

5-nitrobenzene-1,3-dicarboxylic acid (618-88-2) → 3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester (905858-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 24 h / Heating

2: 78 percent / Et₃N / CH₂Cl₂ / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jm0600949

Reference yield: 88.0%

3-[3-(2-ethoxycarbonyl-ethylcarbamoyl)-5-nitro-benzoylamino]-propionic acid ethyl ester (905858-82-4) → 3-[3-amino-5-(2-ethoxycarbonyl-ethylcarbamoyl)-benzoylamino]-propionic acid ethyl ester (905858-83-5)

Guidance literature:

With hydrogen; T-1 Raney Ni; In ethanol; at 20 ℃; under 2585.74 Torr;

DOI:10.1021/jm0600949

upstream raw materials:

5-nitro-1,3-benzenedicarbonylchloride

ethyl β-alaninate hydrochloride

5-nitrobenzene-1,3-dicarboxylic acid

Downstream raw materials:

3-[3-amino-5-(2-ethoxycarbonyl-ethylcarbamoyl)-benzoylamino]-propionic acid ethyl ester

3-[3-{3,5-bis-[3,5-bis-(2-ethoxycarbonyl-ethylcarbamoyl)-phenylcarbamoyl]-benzoylamino}-5-(2-ethoxycarbonyl-ethylcarbamoyl)-benzoylamino]-propionic acid ethyl ester

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