3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide
• CAS No.: 1613145-78-0
• Molecular Formula: C₂₁H₂₂N₂O₂
• Molecular Weight: 334.418
• Mol file: 1613145-78-0.mol

Synonyms:3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide

Chemical Property of 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide

There total 9 articles about 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-amino quinoline (578-66-5) + C12H15ClO2 → 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide (1613145-78-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetlet.2017.01.079

Reference yield:

2,2-dimethyl-3-(4-methoxyphenyl)propionic acid (29206-06-2) → 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide (1613145-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.tetlet.2017.01.079

Reference yield:

8-amino quinoline (578-66-5) + methyl 3-(4-methoxyphenyl)-2,2-dimethylpropanoate (14248-23-8) → 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide (1613145-78-0)

Guidance literature:

8-amino quinoline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 1h; Inert atmosphere;

methyl 3-(4-methoxyphenyl)-2,2-dimethylpropanoate; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201311105

upstream raw materials:

8-amino quinoline

methyl 3-(4-methoxyphenyl)-2,2-dimethylpropanoate

p-methoxybenzyl chloride

2,2-dimethyl-3-(4-methoxyphenyl)propionic acid

Downstream raw materials:

3-(4-methoxybenzyl)-3-methyl-1-(quinolin-8-yl)azetidin-2-one

3-(4-methoxybenzyl)-3-methyl-1-(8-quinolinyl)-2-azetidinone