7-Hydroxy-2-acetamidofluorene

Base Information

• Chemical Name: 7-Hydroxy-2-acetamidofluorene
• CAS No.: 363-49-5
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.274
• Hs Code.: 2924299090
• NSC Number: 40566
• UNII: VGD8AM5AGN
• DSSTox Substance ID: DTXSID30189837
• Nikkaji Number: J821D
• Wikidata: Q27116099
• ChEMBL ID: CHEMBL1908054
• Mol file: 363-49-5.mol

Synonyms:363-49-5;N-(7-hydroxy-9H-fluoren-2-yl)acetamide;7-Hydroxy-2-acetylaminofluorene;7-Hydroxy-2-acetamidofluorene;7-Hydroxy-N-2-fluorenylacetamide;7OH-2AAF;N-(7-Hydroxy-2-fluorenyl)acetamide;7-Hydroxyacetylaminofluorene;ACETAMIDE, N-(7-HYDROXY-9H-FLUOREN-2-YL)-;7-Hydroxy-2-acetaminofluorene;Acetamide, N-(7-hydroxyfluoren-2-yl)-;VGD8AM5AGN;NSC 40566;BRN 2809478;CHEBI:34481;NSC-40566;N-2-(7-Hydroxy-2-fluorenyl)acetamide;Acetamide,N-(7-hydroxy-9H-fluoren-2-yl)-;UNII-VGD8AM5AGN;70H-2AAF;CHEMBL1908054;DTXSID30189837;NSC40566;AKOS030239815;LS-9699;HYDROXY-2-ACETYLAMINOFLUORENE, 7-;FT-0669290;Q27116099

Chemical Property of 7-Hydroxy-2-acetamidofluorene

Chemical Property:

• Melting Point: 230-232°C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 539.3°Cat760mmHg
• PKA: 9.96±0.20(Predicted)
• Flash Point: 279.9°C
• PSA: 49.33000
• Density: 1.33g/cm³
• LogP: 2.99480
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 239.094628657
• Heavy Atom Count: 18
• Complexity: 331

Purity/Quality:

99% ^*data from raw suppliers

7-Hydroxy-2-acetylaminofluorene ^*data from reagent suppliers

Safty Information:

• Safety Statements: Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomp"> x." target="_blank">Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomp

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC2=C(C=C1)C3=C(C2)C=C(C=C3)O
• Uses: 7-Hydroxy-2-acetylaminofluorene (cas# 363-49-5) is a compound useful in organic synthesis.

Technology Process of 7-Hydroxy-2-acetamidofluorene

There total 4 articles about 7-Hydroxy-2-acetamidofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-hydroxy-2-aminofluorene (1953-38-4) + acetic anhydride (108-24-7) → 7-hydroxy-2-acetylaminofluorene (363-49-5)

Guidance literature:

With hydrogenchloride; sodium acetate;

Reference yield:

2-amino-7-nitrofluorene (1214-32-0) → 7-hydroxy-2-acetylaminofluorene (363-49-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous H₂SO₄ / Diazotization

2: zinc; calcium chloride; aqueous ethanol

3: sodium acetate; aqueous hydrochloric acid

With hydrogenchloride; ethanol; sulfuric acid; sodium acetate; calcium chloride; zinc;

Reference yield:

7-hydroxy-2-nitrofluorene (6633-40-5) → 7-hydroxy-2-acetylaminofluorene (363-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; calcium chloride; aqueous ethanol

2: sodium acetate; aqueous hydrochloric acid

With hydrogenchloride; ethanol; sodium acetate; calcium chloride; zinc;

upstream raw materials:

7-hydroxy-2-aminofluorene

acetic anhydride

2-amino-7-hydroxy-fluoren-9-one

2-amino-7-nitrofluorene

Downstream raw materials:

2-Methoxy-7-aminofluoren

N-(7-methoxy-fluoren-2-yl)-acetamide