diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

Base Information

Chemical Name:diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine
CAS No.:1374997-61-1
Molecular Formula:C₂₂H₃₀N₅O₇P
Molecular Weight:507.483
Hs Code.:

diisopropyl (S)-N<sub>2</sub>-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

Synonyms:diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

Suppliers and Price of diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

There total 1 articles about diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 98-88-4
benzoyl chloride

: 138247-69-5,148873-58-9
(R)-9-<2-<(diisopropylphosphono)methoxy>-3-hydroxypropyl>guanine

: 1374997-61-1
diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

Guidance literature:: (R)-9-<2-<(diisopropylphosphono)methoxy>-3-hydroxypropyl>guanine; With pyridine; trimethylsilyl bromide; for 0.5h;

benzoyl chloride; at 20 ℃; for 2h;

With ammonia; In water; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2012.03.066

Reference yield: 78.0%

: 1374997-61-1
diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

: 1374997-70-2
(S)-3-(2-benzamido-6-oxo-1H-purin-9(6H)-yl)-2-[(diisopropylphosphono)methoxy]propanoic acid

Guidance literature:: With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In acetonitrile; at 20 ℃; for 24h; pH=6.7; aq. phosphate buffer;
DOI:10.1016/j.tet.2012.03.066

Reference yield:

: 1374997-61-1
diisopropyl (S)-N₂-benzoyl-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine

: 1374997-80-4
(S)-3-(2-benzamido-6-oxo-1H-purin-9(6H)-yl)-2-(phosphonomethoxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium chlorite; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 24 h / 20 °C / pH 6.7 / aq. phosphate buffer

2: trimethylsilyl bromide / acetonitrile / 20 °C

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trimethylsilyl bromide; In acetonitrile;
DOI:10.1016/j.tet.2012.03.066