N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide

Base Information

• Chemical Name: N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide
• CAS No.: 224313-94-4
• Molecular Formula: C₁₄H₂₁ClN₂O
• Molecular Weight: 268.787
• Mol file: 224313-94-4.mol

Synonyms:N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide

Chemical Property of N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide

There total 1 articles about N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pivaloyl chloride (3282-30-2) → N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide (224313-94-4)

Guidance literature:

Multi-step reaction with 2 steps

2: 65 percent / toluene / 1 h / Heating

In toluene;

DOI:10.1002/jhet.5570360116

Reference yield: 82.0%

N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide (224313-94-4) → 2-tert-butyl-1-(4-chloro-phenyl)-1,4,5,6-tetrahydro-pyrimidine (224314-03-8)

Guidance literature:

With trimethylsilylphosphate; In dichloromethane; for 5h; Heating;

DOI:10.1002/jhet.5570360116

Reference yield:

N-[3-(4-chloro-phenylamino)-propyl]-2,2-dimethyl-propionamide (224313-94-4) → 1-(4-chlorophenyl)-2-tert-butyl-3-methyl-1,4,5,6-tetrahydropyrimidinium iodide

Guidance literature:

Multi-step reaction with 2 steps

1: PPSE / CH₂Cl₂ / 6 h / Heating

2: 79 percent / CH₂Cl₂ / Heating

With PPSE; In dichloromethane;

DOI:10.1002/jhet.5570420410

upstream raw materials:

pivaloyl chloride

Downstream raw materials:

2-tert-butyl-1-(4-chloro-phenyl)-1,4,5,6-tetrahydro-pyrimidine

N-(p-chlorophenyl)-N'-(2,2-dimethylpropyl)trimethylenediamine