(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

Base Information

Chemical Name:(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid
CAS No.:1402636-15-0
Molecular Formula:C₁₅H₂₄N₂O₄S
Molecular Weight:328.433
Hs Code.:

Synonyms:(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

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Chemical Property of (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

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Technology Process of (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

There total 6 articles about (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1402636-14-9
ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

: 1402636-15-0
(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

Guidance literature:: ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate; With water; lithium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In methanol; water;

Reference yield:

: 89490-05-1,21190-87-4
cyclohex-1-enylboronic acid

: 1402636-15-0
(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 6000.6 Torr

3: water; lithium hydroxide / methanol / 20 °C

With water; hydrogen; cesium fluoride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1: Suzuki Coupling;

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1402636-15-0
(2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: MCC-2 / ethanol / Resolution of racemate

2: caesium carbonate / tetrahydrofuran / 16 h / 50 °C

3: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 6000.6 Torr

5: water; lithium hydroxide / methanol / 20 °C

With water; hydrogen; caesium carbonate; cesium fluoride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; 3: Suzuki Coupling;