ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

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Chemical Name:ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate
CAS No.:1402636-14-9
Molecular Formula:C₁₇H₂₈N₂O₄S
Molecular Weight:356.486
Hs Code.:

Synonyms:ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

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Technology Process of ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

There total 7 articles about ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1402636-10-5
ethyl (2R)-4-[4-(cyclohex-1-en-1-yl)-1H-pyrazol-1-yl]-2-methyl-2-(methylsulfonyl)butanoate

: 1402636-14-9
ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; under 6000.6 Torr;

Reference yield:

: 535-13-7
2-chloro-propanoic acid, ethyl ester

: 1402636-14-9
ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 20 h / 77 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 0 - 20 °C

3.1: MCC-2 / ethanol / Resolution of racemate

4.1: caesium carbonate / tetrahydrofuran / 16 h / 50 °C

5.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 6000.6 Torr

With hydrogen; sodium hydride; caesium carbonate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil; 5.1: Suzuki Coupling;

Reference yield:

: 73017-82-0
Ethyl α-(methylsulfonyl)propionate

: 1402636-14-9
ethyl (2R)-4-(4-cyclohexyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 0 - 20 °C

2.1: MCC-2 / ethanol / Resolution of racemate

3.1: caesium carbonate / tetrahydrofuran / 16 h / 50 °C

4.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 6000.6 Torr

With hydrogen; sodium hydride; caesium carbonate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil; 4.1: Suzuki Coupling;