4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one

Base Information

• Chemical Name: 4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one
• CAS No.: 148858-04-2
• Molecular Formula: C₁₃H₁₆N₂O₃
• Molecular Weight: 248.282
• Mol file: 148858-04-2.mol

Synonyms:4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one

Chemical Property of 4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

tert-Butyl3-oxo-3,4-dihydroquinoxaline-1(2H)-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one

There total 5 articles about 4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,2,3,4-tetrahydroquinoxalin-2-one (59564-59-9) → 4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one (148858-04-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 60 - 65 ℃;

DOI:10.1021/jm00032a008

Reference yield:

n-(2-nitrophenyl)glycine ethyl ester (5428-05-7) → 4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one (148858-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 1810.02 Torr

2: 59 percent / K₂CO₃ / tetrahydrofuran / 60 - 65 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00032a008

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one (148858-04-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / diisopropylethylamine / acetonitrile / 80 h / Ambient temperature

2: 88 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 1810.02 Torr

3: 59 percent / K₂CO₃ / tetrahydrofuran / 60 - 65 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1021/jm00032a008

upstream raw materials:

di-tert-butyl dicarbonate

1,2,3,4-tetrahydroquinoxalin-2-one

n-(2-nitrophenyl)glycine ethyl ester

1,2-diamino-benzene