(E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Base Information

• Chemical Name: (E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate
• CAS No.: 1622308-93-3
• Molecular Formula: C₂₆H₂₂O₆S
• Molecular Weight: 462.523
• Mol file: 1622308-93-3.mol

Synonyms:(E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Chemical Property of (E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

There total 4 articles about (E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 4-hydroxycinnamate (3943-97-3) + 2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide (182133-00-2) → (E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate (1622308-93-3)

Guidance literature:

methyl 4-hydroxycinnamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h;

2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 18h;

Reference yield: 97.0%

3-(4-methoxy-phenyl)acrylic acid methyl ester (3901-07-3) + 2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide (182133-00-2) → (E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate (1622308-93-3)

Guidance literature:

3-(4-methoxy-phenyl)acrylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h;

2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 18h;

DOI:10.1021/acs.jmedchem.7b01682

Reference yield:

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (176672-06-3) → (E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)phenyl)acrylate (1622308-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

2.2: 18 h / 80 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

methyl 4-hydroxycinnamate

2-(4'-methoxyphenyl)-3-bromo-6-methoxybenzo[b]thiophene S-oxide

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

Downstream raw materials:

(E)-methyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylate

(E)-3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

(E)-3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylamide

(E)-3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)-N-(3,3,3-trifluoropropyl)acrylamide