3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide

Base Information

Chemical Name:3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide
CAS No.:1401937-67-4
Molecular Formula:C₂₉H₃₆N₂O₃
Molecular Weight:460.616
Hs Code.:

Synonyms:3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide

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Chemical Property of 3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide

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Technology Process of 3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide

There total 16 articles about 3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401938-11-1
[(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid

: 74-89-5
methylamine

: 1401937-67-4
3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: [(16β)-16-(3-carbamoylbenzyl)-17-oxoestra-1(10),2,4-trien-3-yl]acetic acid; methylamine; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

With methanol; sodium tetrahydroborate; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: C₂₈H₃₂N₂O₃

: 1401937-67-4
3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm401639v

Reference yield:

: 1318265-17-6
3-{[(16β,17β)-17-hydroxy-3-(2-hydroxyethyl)estra-1,3,5(10)-trien-16-yl]methyl}benzamide

: 1401937-67-4
3-{[(16β,17β)-17-hydroxy-3-[2-(methylamino)-2-oxoethyl]estra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

1.2: 12 h / 20 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;