{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine

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Chemical Name:{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine
CAS No.:1075194-91-0
Molecular Formula:C₂₆H₁₉F₃N₄
Molecular Weight:444.459
Hs Code.:

Synonyms:{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine

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Chemical Property of {4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine

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Technology Process of {4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine

There total 8 articles about {4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1075194-88-5
2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

: 1075194-91-0
{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine

Guidance literature:: With sodium t-butanolate; CyJohnPhos; palladium diacetate; In toluene; at 180 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 1075194-91-0
{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / methanol / 24 h / 20 °C / Reflux

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -70 °C

2.2: -70 - 20 °C

3.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane / 20 °C

4.1: 2 h / 130 °C / Inert atmosphere; Noeat (no solvent)

5.1: 1,4-diaza-bicyclo[2.2.2]octane / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 120 °C

6.1: trichlorophosphate / 1.5 h / 120 °C

7.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 0.5 h / 20 °C

7.2: 10 h / 20 °C

8.1: CyJohnPhos; sodium t-butanolate / palladium diacetate / toluene / 0.17 h / 180 °C / Microwave irradiation

With 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium; sulfuric acid; dihydrogen peroxide; sodium hydride; sodium t-butanolate; CyJohnPhos; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; methyltrioxorhenium(VII); In tetrahydrofuran; methanol; hexane; dichloromethane; Pionier 2076; N,N-dimethyl-formamide; toluene;

Reference yield:

: 610270-86-5
4-[2-(4-fluorophenyl)-1,1-dimethoxyethyl]pyridin-1-ol

: 1075194-91-0
{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / 130 °C / Inert atmosphere; Noeat (no solvent)

2.1: 1,4-diaza-bicyclo[2.2.2]octane / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 120 °C

3.1: trichlorophosphate / 1.5 h / 120 °C

4.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 0.5 h / 20 °C

4.2: 10 h / 20 °C

5.1: CyJohnPhos; sodium t-butanolate / palladium diacetate / toluene / 0.17 h / 180 °C / Microwave irradiation

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride; sodium t-butanolate; CyJohnPhos; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; In Pionier 2076; N,N-dimethyl-formamide; toluene;