trimethylsilyl 4-(cyclohexyl)butyrate

Base Information

• Chemical Name: trimethylsilyl 4-(cyclohexyl)butyrate
• CAS No.: 934415-18-6
• Molecular Formula: C₁₃H₂₆O₂Si
• Molecular Weight: 242.434
• Mol file: 934415-18-6.mol

Synonyms:trimethylsilyl 4-(cyclohexyl)butyrate

Chemical Property of trimethylsilyl 4-(cyclohexyl)butyrate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of trimethylsilyl 4-(cyclohexyl)butyrate

There total 1 articles about trimethylsilyl 4-(cyclohexyl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

chloro-trimethyl-silane (75-77-4) + 4-cyclohexylbutanoic acid (4441-63-8) → trimethylsilyl 4-(cyclohexyl)butyrate (934415-18-6)

Guidance literature:

4-cyclohexylbutanoic acid; With pyridine; In tetrahydrofuran; at 0 ℃; for 0.5h;

chloro-trimethyl-silane; With 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.tet.2007.01.026

Reference yield: 78.0%

chloro-trimethyl-silane (75-77-4) + trimethylsilyl 4-(cyclohexyl)butyrate (934415-18-6) → 2-(cyclohexylethyl)-1,1-bis(trimethylsilyloxy)ethene (918882-68-5)

Guidance literature:

trimethylsilyl 4-(cyclohexyl)butyrate; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h;

DOI:10.1016/j.tet.2007.01.026

Reference yield:

trimethylsilyl 4-(cyclohexyl)butyrate (934415-18-6) → 3-(cyclohexylethyl)-4-hydroxymaleic anhydride

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1,1,3,3,3-hexamethyldisilazane; n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 78 percent / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

2.1: trimethyl-trifluoromethanesulfonate / CH₂Cl₂ / 12 h / -78 - 20 °C

2.2: 63 percent / CH₂Cl₂ / 3 h / 20 °C

With n-butyllithium; trimethyl-trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.tet.2007.01.026

upstream raw materials:

chloro-trimethyl-silane

4-cyclohexylbutanoic acid

Downstream raw materials:

2-(cyclohexylethyl)-1,1-bis(trimethylsilyloxy)ethene