2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole

Base Information

Chemical Name:2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole
CAS No.:1355646-00-2
Molecular Formula:C₂₂H₁₈Cl₂F₃N₃O₂S
Molecular Weight:516.371
Hs Code.:

Synonyms:2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole

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Chemical Property of 2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole

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Technology Process of 2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole

There total 4 articles about 2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazol-3-yl]-2-methylbenzoyl chloride

: 2-aminomethyl-4,5-dihydrothiazole hydrochloride

: 1355646-00-2
2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole

Guidance literature:: 2-aminomethyl-4,5-dihydrothiazole hydrochloride; With triethylamine; In chloroform; for 0.5h;

4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazol-3-yl]-2-methylbenzoyl chloride; In chloroform; at 0 - 20 ℃;

Reference yield:

: 864725-62-2
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

: 1355646-00-2
2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 1 h / Reflux

2.1: triethylamine / chloroform / 0.5 h

2.2: 0 - 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In chloroform; toluene;

Reference yield:

: 864736-32-3
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester

: 1355646-00-2
2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / Reflux

1.2: pH 1

2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 1 h / Reflux

3.1: triethylamine / chloroform / 0.5 h

3.2: 0 - 20 °C

With thionyl chloride; water; triethylamine; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; chloroform; toluene;