864736-32-3

Basic information

• Product Name: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester
• Synonyms: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester
• CAS NO: 864736-32-3
• Molecular Weight: 432.226
• Mol File: 864736-32-3.mol

Chemical Properties

• CAS DataBase Reference: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester(864736-32-3)
• EPA Substance Registry System: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester(864736-32-3)

Safety Data

• Hazardous Substances Data: 864736-32-3(Hazardous Substances Data)

Upstream product

• 864725-22-4 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1437051-96-1 4-(chloro(hydroxyimino)methyl)-2-methylbenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 1437051-93-8 (4-(hydroxyimino)methyl)-2-methylbenzoic acid 
• 130336-16-2 3,5-dichloro-2,2,2-trifluoroacetophenone 
• 103261-67-2 4-cyano-2-methylbenzoic acid methyl ester 
• 1263483-49-3 methyl 4-[amino(hydroxyimino)methyl]-2-methylbenzoate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1164268-94-3 5-bromo-4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl-benzoic acid methyl ester 
• 1097633-38-9 4-[5-(3,5-dichlorophenyl)-4-methyl-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoic acid methyl ester 
• 1210963-22-6 4-[5-(3,5-dichlorophenyl)-4,4-difluoro-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoic acid methyl ester 
• 1233037-25-6 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-thiobenzoic acid o-methyl ester 
• 864731-61-3 A₁₄₄₃ 
• 1355645-49-6 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-N-(1-ethyl-4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylbenzamide 
• 1355646-33-1 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-N-(4,5-dihydrothiazol-2-yl)-2-methylbenzamide 
• 1355646-00-2 2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole 
• 1355645-65-6 2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole-4-carboxylic acid ethyl ester 
• 864731-29-3 N-cyanomethyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzamide 
• 864725-62-2 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid 
• 930110-36-4 (4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)methanol 
• 1097633-31-2 methyl 4-((1Z,2Z)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-1-(hydroxyimino)-2-butenyl)-2-methyl-benzoate 
• 1097633-40-3 4-[5-(3,5-dichlorophenyl)-4-chloro-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoic acid methyl ester 

Relevant articles and documents

Method for preparing fluralana intermediate, prepared intermediate and application of fluralana intermediate

A method for preparing a fluralana intermediate, provided by the invention, comprises the following steps: carrying out nucleophilic addition reaction on 1-(3, 5-dichlorophenyl)-2, 2, 2-trifluoroethanone, carrying out acidolysis, reacting with a Grignard reagent, carrying out oxidation, carrying out oxidation cyclization reaction, reacting with hydroxyl(toluenesulfonyloxy)benzene iodide, and reacting with a trimethoxyphosphorus solution to finally generate the fluralan. In the preparation process, a catalyst and dimethoxy zinc are not needed, ultralow-temperature reaction conditions of -78 DEG C are not needed, operation is easy and convenient, meanwhile, reagents such as ozone and dimethyl sulfide which are harmful to the environment are replaced, and the method is more environmentally friendly. The invention also provides the intermediate for preparing the fluralan.

Preparation method of fluralaner intermediate

The invention relates to a preparation method of a fluralaner intermediate, which comprises the following steps of: carrying out addition reaction on 4-cyano-2-methyl toluate serving as an initial reactant and hydroxylamine to obtain 4-formamide oxime-2-methyl toluate, carrying out diazotization and denitrification reaction in sequence to obtain a halogen oxime compound, and finally carrying out addition cyclization reaction on the halogen oxime compound and 1, 3-dichloro-5-(1-trifluoromethyl-vinyl) benzene to obtain a target product fluralaner intermediate. Amidoxime is prepared through an addition reaction, and then halogenated oxime is prepared through a diazotization reaction. Compared with reduction, oximation and chlorination reactions in the prior art, the preparation process is greatly simplified, the process conditions are mild, safe and environmentally friendly, the yield can reach 70% or above, and the method is suitable for industrial production.

Synthetic method of isoxazoline anthelmintic

The invention belongs to the technical field of chemical drug synthesis, and particularly relates to a synthesis method of an isoxazoline anthelmintic. The method is characterized in that the isoxazoline anthelmintic is fluralaner, and the method includes

AZOLINE SUBSTITUTED ISOXAZOLINE BENZAMIDE COMPOUNDS FOR COMBATING ANIMAL PESTS

Substituted azoline-containing isoxazoline compounds and derivatives for combating animal pests The invention relates to substituted azoline-containing isoxazoline benzamide compounds of the general formula (I), to the enantiomers, diastereomers and salts

IMINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS

The present invention relates to imine compounds which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

INSECTICIDAL COMPOUNDS

A compound of formula (I), wherein A1, A2, A3, A4, G1, L, R1, R2, R3, R4, Y1, Y2 and Y3 are as defined in claim 1; or a sal

ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT

An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc., Y ia halogen atm, C 1 -C 6 alkyl, etc., R 1 is C 1 -C 12 alkyl arbitrarily substituted with R 16 , C 3 -C 12 alkenyl, arbitrarily substituted with R 16 is oxygen atom or sulfur atom, -N(R 20 )R 19 , etc., R 2 is hydrogen atom, C 1 -C 4 alkoxy C 1 -C 6 alkyl, etc., R 3 is C 1 -C 6 haloalkyl, etc., R 16 is halogen atom, cyano, phenyl substituted with (Z) p1 , D-1 to D-60, E-1 to E-49, etc., R 19 is phenyl, phenyl substituted with (Z) p1 , etc., R 20 is hydrogen atom, C 1 -C 6 alkyl, etc., Z is halogen atom, nitro, C 1 -C 4 alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.