Technology Process of (+/-)-16-oxa-14,15-dinor-13,16-inter-o-phenyleneleucotriene A4 methyl ester
There total 5 articles about (+/-)-16-oxa-14,15-dinor-13,16-inter-o-phenyleneleucotriene A4 methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 65 percent / PBr3, pyridine / diethyl ether / 1.) -30 deg C, 1 h; 2.) 20 deg C, 3 h
2: 4.13 g / acetonitrile / 144 h / Heating; sealed glass tube
3: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 15 min; 2.) HMPTA, room temp.
With
pyridine; n-butyllithium; phosphorus tribromide;
In
diethyl ether; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) ozone-oxygen; 2.) sodium borohydride / 1.) methanol, 10 deg C; 2.) room temp.
2: 65 percent / PBr3, pyridine / diethyl ether / 1.) -30 deg C, 1 h; 2.) 20 deg C, 3 h
3: 4.13 g / acetonitrile / 144 h / Heating; sealed glass tube
4: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 15 min; 2.) HMPTA, room temp.
With
pyridine; sodium tetrahydroborate; n-butyllithium; oxygen; phosphorus tribromide; ozone;
In
diethyl ether; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / dimethylformamide / 6 h / 20 °C
2: 1.) ozone-oxygen; 2.) sodium borohydride / 1.) methanol, 10 deg C; 2.) room temp.
3: 65 percent / PBr3, pyridine / diethyl ether / 1.) -30 deg C, 1 h; 2.) 20 deg C, 3 h
4: 4.13 g / acetonitrile / 144 h / Heating; sealed glass tube
5: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 15 min; 2.) HMPTA, room temp.
With
pyridine; sodium tetrahydroborate; n-butyllithium; oxygen; phosphorus tribromide; ozone;
In
diethyl ether; N,N-dimethyl-formamide; acetonitrile;
