4-bromophenyl 2-(4-morpholinyl)-2-oxoethyl ether

Base Information

• Chemical Name: 4-bromophenyl 2-(4-morpholinyl)-2-oxoethyl ether
• CAS No.: 110009-59-1
• Molecular Formula: C₁₂H₁₄BrNO₃
• Molecular Weight: 300.152
• Mol file: 110009-59-1.mol

Synonyms:C₁₂H₁₄BrNO₃

Chemical Property of 4-bromophenyl 2-(4-morpholinyl)-2-oxoethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromophenyl 2-(4-morpholinyl)-2-oxoethyl ether

There total 3 articles about 4-bromophenyl 2-(4-morpholinyl)-2-oxoethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

morpholine (110-91-8,99108-56-2) + (4-bromophenoxy)acetic acid (1878-91-7) → C12H14BrNO3 (110009-59-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;

Reference yield:

4-bromo-phenol (106-41-2) → C12H14BrNO3 (110009-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetone / 16 h / 0 - 20 °C / Inert atmosphere

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 0 - 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

Reference yield:

ethyl 2-(4-bromophenoxy)acetate (6964-29-0) → C12H14BrNO3 (110009-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 0 - 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-phenol

morpholine

(4-bromophenoxy)acetic acid

ethyl 2-(4-bromophenoxy)acetate

Downstream raw materials:

2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

C₃₂H₃₃N₅O₆

1-[(morpholin-4-yl)-carbonylmethyloxy]-4-[4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl]-benzene