(-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide

Base Information

Chemical Name:(-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide
CAS No.:936628-12-5
Molecular Formula:C₁₈H₂₈N₂O₃
Molecular Weight:320.432
Hs Code.:

(-)-(R)-N<sup>2</sup>-(tert-butoxycarbonyl)-N<sup>1</sup>-(2,6-dimethylphenyl)-N<sup>1</sup>-ethylalaninamide

Synonyms:(-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide

Chemical Property:

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Technology Process of (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide

There total 4 articles about (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 151416-30-7
(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)alaninamide

: 75-03-6
ethyl iodide

: 936628-12-5
(-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide

Guidance literature:: With barium dihydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm061078e

Reference yield:

: 3744-87-4,7764-95-6,15761-38-3
Boc-(R)-Ala

: 936628-12-5
(-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine / CHCl₃ / 6 h / Heating

2: 50 percent / Ba(OH)2*8H₂O / H₂O; dimethylformamide / 12 h / 20 °C

With barium dihydroxide; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine; In chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm061078e

Reference yield:

: 73371-96-7
2-<<(tert-butoxycarbonyl)oxy>imino>-2-phenylacetonitrile

: 936628-12-5
(-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-ethylalaninamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / H₂O; dioxane / 20 °C

2: 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine / CHCl₃ / 6 h / Heating

3: 50 percent / Ba(OH)2*8H₂O / H₂O; dimethylformamide / 12 h / 20 °C

With barium dihydroxide; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm061078e