2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester

Base Information

Chemical Name:2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester
CAS No.:114957-77-6
Molecular Formula:C₂₆H₂₇NO₆
Molecular Weight:449.503
Hs Code.:

Synonyms:2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester

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Chemical Property of 2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester

Chemical Property:

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Technology Process of 2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester

There total 4 articles about 2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15802-62-7,15802-63-8,620-80-4
(Z)-ethyl 2-benzylidenacetoacetate

: 3929-70-2
ethyl 5-phenyl-3-isoxazoleacetate

: 114957-77-6
2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jm00403a030

Reference yield:

: 3590-37-2
ethyl 3-nitropropanoate

: 114957-77-6
2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 5.1 percent / triethylamine, phosphorous oxychloride / CHCl₃ / Heating

2: lithium diisopropylamide / tetrahydrofuran / -78 °C

With triethylamine; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; chloroform;
DOI:10.1021/jm00403a030

Reference yield:

: 86969-12-2
α-benzoylacetoacetic acid ethyl ester

: 114957-77-6
2-Acetyl-3-phenyl-4-(5-phenyl-isoxazol-3-yl)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 6.9 g / hydroxylamine hydrochloride / pyridine / 1.) room temperature, 20 min, 2.) reflux, 1 h

2: lithium diisopropylamide / tetrahydrofuran / -78 °C

With hydroxylamine hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; pyridine;
DOI:10.1021/jm00403a030