5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Base Information

Chemical Name:5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole
CAS No.:1053729-53-5
Molecular Formula:C₂₇H₃₉NO₃Si
Molecular Weight:453.697
Hs Code.:

5-benzhydryl-4-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-<i>c</i>]pyrrole

Synonyms:5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Suppliers and Price of 5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

There total 7 articles about 5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 77-76-9
2,2-dimethoxy-propane

: 208253-74-1
5-O-tert-butyldimethylsilyl-N-diphenylmethyl-1,4-dideoxy-1,4-imino-D-lyxytol

: 1053729-53-5
5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; Heating;
DOI:10.1021/jo000527u

Reference yield:

: 208253-71-8
(2R,3R)-N-diphenylmethylene-1-O-tert-butyldimethylsilyl-3-O-trimethylacetyl-2-amino-4-pentene-1,2-diol

: 1053729-53-5
5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: K₂Os(OH)4; K₃Fe(CN)6; K₂CO₃ / 2-methyl-propan-2-ol; H₂O / 20 °C / pH 12

2: 84 percent / LiBH₄ / tetrahydrofuran / Heating

3: 90 percent / PPh₃; CCl₄; Et₃N / dimethylformamide / 17 h / 20 °C

4: 84 percent / CSA / CH₂Cl₂ / Heating

With tetrachloromethane; lithium borohydride; K₂Os(OH)4; camphor-10-sulfonic acid; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: dihydroxylation / 2: Reduction / 3: cyclocondensation / 4: cyclocondensation;
DOI:10.1021/jo000527u

Reference yield:

: 208253-70-7
(2R,3R)-N-diphenylmethylene-1-O-tert-butyldimethylsilyl-2-amino-4-pentene-1,2-diol

: 1053729-53-5
5-benzhydryl-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / DMAP; pyridine / 60 h / 0 - 20 °C

2: K₂Os(OH)4; K₃Fe(CN)6; K₂CO₃ / 2-methyl-propan-2-ol; H₂O / 20 °C / pH 12

3: 84 percent / LiBH₄ / tetrahydrofuran / Heating

4: 90 percent / PPh₃; CCl₄; Et₃N / dimethylformamide / 17 h / 20 °C

5: 84 percent / CSA / CH₂Cl₂ / Heating

With pyridine; tetrachloromethane; dmap; lithium borohydride; K₂Os(OH)4; camphor-10-sulfonic acid; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Acylation / 2: dihydroxylation / 3: Reduction / 4: cyclocondensation / 5: cyclocondensation;
DOI:10.1021/jo000527u