(2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

Base Information

Chemical Name:(2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine
CAS No.:1258232-69-7
Molecular Formula:C₃₆H₄₆B₂FNO₆
Molecular Weight:629.385
Hs Code.:

Synonyms:(2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

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Chemical Property of (2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

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Technology Process of (2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

There total 3 articles about (2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: diboron

: 1258232-68-6
(2S,3R,4R,5S)-2,5-bis(4-bromophenyl)-1-(4-fluorophenyl)-3,4-dimethoxypyrrolidine

: 1258232-69-7
(2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

Guidance literature:: With potassium acetate; In 1,4-dioxane;

Reference yield:

: 1258232-67-5
(2S,3R,4R,5S)-2,5-bis(4-bromophenyl)-1-(4-fluorophenyl)pyrrolidine-3,4-diol

: 1258232-69-7
(2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; mineral oil

2: potassium acetate / 1,4-dioxane

With potassium acetate; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1258232-69-7
(2S,3R,4R,5S)-1-(4-fluorophenyl)-3,4-dimethoxy-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: iodobenzene diacetic acid / methanol-dichloromethane; aq. sulfuric acid; ethanol; ethyl acetate

2: tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; mineral oil

3: potassium acetate / 1,4-dioxane

With iodobenzene diacetic acid; potassium acetate; In tetrahydrofuran; 1,4-dioxane; methanol-dichloromethane; aq. sulfuric acid; ethanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;