2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

Chemical Name:2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.:1416367-16-2
Molecular Formula:C₁₁H₁₄BClFNO₂
Molecular Weight:257.5
Hs Code.:

Synonyms:2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Suppliers and Price of 2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 95+%
10g
$ 408.00

AOBChem
2-Chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97%
5g
$ 335.00

Total 3 raw suppliers

Chemical Property of 2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 3 articles about 2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 73183-34-3
bis(pinacol)diborane

: 1416367-16-2
2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 2-chloro-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; at 80 ℃; for 18h; Overall yield = 82 %; Overall yield = 32 mg; Inert atmosphere; Glovebox;

Reference yield:

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 937595-71-6
(2-chloro-3-fluoropyridin-4-yl)boronic acid

: 1416367-16-2
2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: With magnesium sulfate; In diethyl ether; at 20 ℃; for 16h;
DOI:10.1021/ol400289v

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1416367-16-2
2-chloro-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 2-chloro-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; at 20 ℃; Glovebox; Inert atmosphere;

With 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; at 20 ℃; Glovebox; Inert atmosphere;

2-chloro-3-fluoropyridine; In tetrahydrofuran; at 20 ℃; Reagent/catalyst; Overall yield = 77 percent; Overall yield = 199 mg; regioselective reaction; Glovebox; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02299