2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

Base Information

Chemical Name:2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione
CAS No.:1394868-08-6
Molecular Formula:C₂₆H₁₅Cl₂NO₃S
Molecular Weight:492.382
Hs Code.:

Synonyms:2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

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Technology Process of 2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

There total 1 articles about 2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1027493-29-3
2-[5-bromo-3-(4-chloro-benzoyl)-4-methyl-thiophen-2-yl]-isoindole-1,3-dione

: 1679-18-1
4-Chlorophenylboronic acid

: 1394868-08-6
2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; cesium fluoride; In 1,4-dioxane; for 5.5h; Inert atmosphere; Heating;
DOI:10.1021/jm3007504

Reference yield: 88.0%

: 1394868-08-6
2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

: 1394868-10-0
2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-(4-chlorophenyl)thiophen-2-yl]isoindoline-1,3-dione

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In 1,2-dichloro-ethane; for 3h; Inert atmosphere; Reflux;
DOI:10.1021/jm3007504

Reference yield:

: 1394868-08-6
2-[3-(4-chlorobenzoyl)-5-(4-chlorophenyl)-4-methylthiophen-2-yl]isoindoline-1,3-dione

: 1394867-67-4
C₂₉H₂₃Cl₃F₃N₃OS

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / 1,2-dichloro-ethane / 3 h / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice

3: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; hydrazine hydrate; triethylamine; dibenzoyl peroxide; In ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm3007504