3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

Base Information

Chemical Name:3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester
CAS No.:125376-03-6
Molecular Formula:C₂₆H₂₆N₂O₆
Molecular Weight:462.502
Hs Code.:

Synonyms:3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

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Chemical Property of 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

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Technology Process of 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

There total 8 articles about 3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13512-59-9
N-(tert-butyloxycarbonyl)-O-(phenylmethyl)-L-tyrosine 4-nitrophenol ester

: 121-44-8
triethylamine

: 141-75-3
butyryl chloride

: 125376-03-6
3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

Guidance literature:: With trifluoroacetic acid; In chloroform;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 172992-35-7
3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid

: 125376-03-6
3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; at 20 ℃; for 4h;
DOI:10.1021/ja0705801

Reference yield:

: 34805-17-9
methyl 2S-amino-3-(4-benzyloxyphenyl)propionate hydrochloride

: 125376-03-6
3-(4-benzyloxy-phenyl)-2-butyrylamino-propionic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

2: aq. LiOH / tetrahydrofuran / 16 h / 20 °C

3: 4.73 g / 1,3-dicyclohexylcarbodiimide / CH₂Cl₂; ethyl acetate / 4 h / 20 °C

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja0705801