N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide

Base Information

Chemical Name:N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide
CAS No.:1108792-76-2
Molecular Formula:C₃₄H₃₈ClF₃N₄O₃
Molecular Weight:643.149
Hs Code.:

Synonyms:N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide

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Chemical Property of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide

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Technology Process of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide

There total 5 articles about N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1108792-84-2
6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxylic acid

: 1108698-65-2
(2R,3S)-3-amino-4-phenyl-1-{[3-(trifluoromethyl)benzyl]amino}butan-2-ol hemi-hydrochloride

: 1108792-76-2
N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 16751-59-0
4-heptylamine

: 1108792-76-2
N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylaluminum / ethyl acetate; toluene / 20 - 100 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 16 h / Inert atmosphere; Reflux

3: water; potassium acetate; triphenylphosphine; potassium iodide / palladium diacetate / N,N-dimethyl-formamide / 20 - 100 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With water; trimethylaluminum; sodium ethanolate; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium iodide; palladium diacetate; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 289039-84-5
methyl 2-amino-5-chloro-3-iodobenzoate

: 1108792-76-2
N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-6-chloro-4-oxo-3-(1-propylbut-1-yl)-3,4-dihydroquinazolin-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylaluminum / ethyl acetate; toluene / 20 - 100 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 16 h / Inert atmosphere; Reflux

3: water; potassium acetate; triphenylphosphine; potassium iodide / palladium diacetate / N,N-dimethyl-formamide / 20 - 100 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With water; trimethylaluminum; sodium ethanolate; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium iodide; palladium diacetate; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;