diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester

Base Information

• Chemical Name: diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester
• CAS No.: 936910-20-2
• Molecular Formula: C₂₅H₁₉N₂O₂P
• Molecular Weight: 410.412
• Mol file: 936910-20-2.mol

Synonyms:diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester

Chemical Property of diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester

There total 4 articles about diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-hydroxy-2-phenylbenzimidazole (5496-07-1,498539-13-2) + Diphenylphosphinic chloride (1499-21-4) → diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester (936910-20-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1055/s-2007-965918

Reference yield:

benzyl bromide (100-39-0) → diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester (936910-20-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / NaH / tetrahydrofuran / 4 h / 80 °C

2: 98 percent / H₂ / Pd/C / methanol / 0.25 h / 20 °C

3: 63 percent / Et₃N / CH₂Cl₂ / 0 °C

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1055/s-2007-965918

Reference yield:

2-nitro-aniline (88-74-4) → diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester (936910-20-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / NaH / tetrahydrofuran / 4 h / 80 °C

2: 98 percent / H₂ / Pd/C / methanol / 0.25 h / 20 °C

3: 63 percent / Et₃N / CH₂Cl₂ / 0 °C

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1055/s-2007-965918

upstream raw materials:

N-hydroxy-2-phenylbenzimidazole

Diphenylphosphinic chloride

benzyl bromide

2-nitro-aniline

Downstream raw materials:

2-phenyl-1-[(phenylcarbonyl)oxy]-1H-benzimidazole