5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate

Base Information

Chemical Name:5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate
CAS No.:1200463-25-7
Molecular Formula:C₂₁H₃₁N₄O₁₆P₃
Molecular Weight:688.416
Hs Code.:

Synonyms:5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate

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Chemical Property of 5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate

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Technology Process of 5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate

There total 7 articles about 5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200461-36-4
5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

: 1200463-25-7
5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate / 3 h / 0 °C / Inert atmosphere

2.1: tributyl-amine; bis(tri-n-butylammonium) pyrophosphate / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

2.2: 1 h / 20 °C / pH 7.5 / Inert atmosphere; aq. buffer

With tributyl-amine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; bis(tri-n-butylammonium) pyrophosphate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516

Reference yield:

: C₂₃H₃₃N₄O₁₀P

: 1200463-25-7
5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate

Guidance literature:: C₂₃H₃₃N₄O₁₀P; With tributyl-amine; bis(tri-n-butylammonium) pyrophosphate; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

In N,N-dimethyl-formamide; at 20 ℃; for 1h; pH=7.5; Inert atmosphere; aq. buffer;
DOI:10.1002/anie.201106516

Reference yield:

: 1200461-32-0
3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

: 1200463-25-7
5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / 1,4-dioxane / 10 h / 90 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate / 3 h / 0 °C / Inert atmosphere

4.1: tributyl-amine; bis(tri-n-butylammonium) pyrophosphate / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

4.2: 1 h / 20 °C / pH 7.5 / Inert atmosphere; aq. buffer

With tributyl-amine; tetrabutyl ammonium fluoride; ammonia; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; bis(tri-n-butylammonium) pyrophosphate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516