3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

Base Information

Chemical Name:3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine
CAS No.:1200461-32-0
Molecular Formula:C₄₈H₇₇N₃O₁₀SSi₂
Molecular Weight:944.39
Hs Code.:

3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

Synonyms:3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

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Chemical Property of 3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

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Technology Process of 3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

There total 7 articles about 3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 1200462-94-7
3',5‘-O-bis(tert-butylmethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxyuridine

: 1200461-32-0
3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 36h; Inert atmosphere;
DOI:10.1002/anie.201106516

Reference yield:

: 1200463-02-0
(S)-1-(2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1200461-32-0
3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1 h / 110 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 36 h / 20 °C / Inert atmosphere

With dmap; triethylamine; In dichloromethane;
DOI:10.1002/anie.201106516

Reference yield:

: 1028383-90-5
N³-tert-butyloxycarbonyl-5-bromomethyl-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyuridine

: 1200461-32-0
3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1 h / 110 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 36 h / 20 °C / Inert atmosphere

With dmap; triethylamine; In dichloromethane;
DOI:10.1002/anie.201106516