(R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate

Base Information

Chemical Name:(R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate
CAS No.:1422051-75-9
Molecular Formula:C₂₆H₂₇F₂N₅O₄S
Molecular Weight:543.594
Hs Code.:

Synonyms:(R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate

There total 4 articles about (R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259279-57-6
5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1422051-74-8
(R)-methyl 3-((2-chloro-5-fluoropyrimidin-4-yl)amino)-4,4-dimethylpentanoate

: 1422051-75-9
(R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; water; at 115 ℃; for 2h; Inert atmosphere; Sealed tube;

Reference yield:

: 1417421-99-8
3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1422051-75-9
(R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 2-methyltetrahydrofuran; water / 2 h / 115 °C / Inert atmosphere; Sealed tube

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; XPhos; In 2-methyltetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1190309-71-7
3-bromo-5-fluoro-1H-pyrrolo-[2,3-b]pyridine

: 1422051-75-9
(R)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 2-methyltetrahydrofuran; water / 2 h / 115 °C / Inert atmosphere; Sealed tube

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; sodium hydride; XPhos; In 2-methyltetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;