2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline

Base Information

Chemical Name:2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline
CAS No.:289507-32-0
Molecular Formula:C₂₁H₂₂BrNO₅
Molecular Weight:448.313
Hs Code.:

Synonyms:2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline

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Chemical Property of 2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline

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Technology Process of 2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline

There total 5 articles about 2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxyisoquinolinium bromide

: 289507-32-0
2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline

Guidance literature:: With potassium hydroxide; potassium hexacyanoferrate(III); In water; for 0.5h; Heating;
DOI:10.1021/ol006213a

Reference yield:

: 63375-81-5
2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine

: 289507-32-0
2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / chloroform / 20 h / 20 °C / Inert atmosphere

2: carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; silver hexafluoroantimonate; zinc diacetate / 2,2,2-trifluoroethanol / 48 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube

With silver hexafluoroantimonate; carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; zinc diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; 2,2,2-trifluoroethanol;
DOI:10.1021/acs.orglett.0c02016

Reference yield:

: 69327-12-4
1-bromo-2-(2-bromoethyl)-4,5-dimethoxybenzene

: 289507-32-0
2-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / acetonitrile / 6.5 h / 100 °C

2: 87 percent / K₃[Fe(CN)6]; KOH / H₂O / 0.5 h / Heating

With potassium hydroxide; potassium hexacyanoferrate(III); In water; acetonitrile; 1: Substitution / 2: Oxidation;
DOI:10.1021/ol006213a