N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide

Base Information

Chemical Name:N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide
CAS No.:867182-06-7
Molecular Formula:C₁₆H₂₄BNO₃
Molecular Weight:289.182
Hs Code.:

Synonyms:N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide

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Technology Process of N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide

There total 6 articles about N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 75-09-2
dichloromethane

: 108-24-7
acetic anhydride

: 195062-59-0
2-methylphenylboronic acid pinacol ester

: 867182-06-7
N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide

Guidance literature:: dichloromethane; 2-methylphenylboronic acid pinacol ester; With n-butyllithium; In tetrahydrofuran; at 20 ℃;

With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 16h;

acetic anhydride; With acetic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetasy.2005.08.008

Reference yield:

: C₂₀H₃₈BNO₂Si₂

: 108-24-7
acetic anhydride

: 867182-06-7
N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide

Guidance literature:: With acetic acid; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1246/cl.2009.664

Reference yield:

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 867182-06-7
N-[(2-methylphenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / tetrahydrofuran / 1 h / 20 °C

2.1: n-BuLi / tetrahydrofuran / 20 °C

2.2: lithium bis-trimethylsilylamide / tetrahydrofuran / 16 h / 20 °C

2.3: 78 percent / acetic acid / tetrahydrofuran / 20 °C

With n-butyllithium; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2005.08.008