α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

Base Information

• Chemical Name: α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol
• CAS No.: 111627-25-9
• Molecular Formula: C₂₅H₂₅F₂NO
• Molecular Weight: 393.476
• Mol file: 111627-25-9.mol

Synonyms:α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

Chemical Property of α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

There total 4 articles about α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

N-benzyl isonipecotic acid ethyl ester (24228-40-8) + 4-flourophenylmagnesium bromide (352-13-6) → α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol (111627-25-9)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 28h; Heating;

Reference yield:

N-benzyl isonipecotic acid ethyl ester (24228-40-8) + 1-Bromo-4-fluorobenzene (460-00-4) → α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol (111627-25-9)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight;

DOI:10.1021/jm00121a022

Reference yield:

4-carbethoxypiperidine (1126-09-6) → α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol (111627-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / K₂CO₃ / ethanol / 18 h / Heating

2: 21 percent / diethyl ether; tetrahydrofuran / 28 h / Heating

With potassium carbonate; In tetrahydrofuran; diethyl ether; ethanol;

upstream raw materials:

N-benzyl isonipecotic acid ethyl ester

1-Bromo-4-fluorobenzene

4-flourophenylmagnesium bromide

4-carbethoxypiperidine

Downstream raw materials:

4-[bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine

α,α-bis(4-fluorophenyl)-1-[3-[2-(phenylmethoxy)phenoxy]propyl]-4-piperidinemethanol

3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid methyl ester

[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-acetic acid methyl ester