Bis(4-fluorophenyl)(piperidin-4-yl)methanol

Base Information

• Chemical Name: Bis(4-fluorophenyl)(piperidin-4-yl)methanol
• CAS No.: 60284-98-2
• Molecular Formula: C18H19F2NO
• Molecular Weight: 303.352
• DSSTox Substance ID: DTXSID10458871
• Nikkaji Number: J3.458.509A
• Wikidata: Q82282421
• Mol file: 60284-98-2.mol

Synonyms:60284-98-2;bis(4-fluorophenyl)(piperidin-4-yl)methanol;bis(4-fluorophenyl)-piperidin-4-ylmethanol;alpha,alpha-bis-(4-Fluorophenyl)piperidine-4-methanol;SCHEMBL2306732;DTXSID10458871;XCBRQKMHQPWSGQ-UHFFFAOYSA-N;Di(4-fluorophenyl)(4-piperidinyl)methanol;4-[bis(4-fluorophenyl)hydroxymethyl]piperidine;4-[bis(4-fluorophenyl)hydroxy-methyl]piperidine;alpha,alpha-bis(4-fluorophenyl)-4-piperidinemethanol;alpha,alpha-bis(p-fluorophenyl)-4-piperidinemethanol;[alpha,alpha-bis(p-fluorophenyl)]4-piperidinemethanol;alpha, alpha-bis(p-fluorophenyl)-4-piperidinemethanol;alpha,alpha-bis (p-fluorophenyl)-4-piperidinemethanol;alpha,alpha-bis(4-fluorophenyl)-4-piperidine methanol;alpha,alpha-bis(4-fluorophenyl)-4-piperidine-methanol;alpha,alpha-bis-(p-fluorophenyl)-4-piperidinemethanol;[alpha,alpha-bis (p-fluorophenyl)]-4-piperidinemethanol;[alpha,alpha-bis(4 -fluorophenyl)]-4-piperidinemethanol;[alpha,alpha-bis(4-fluorophenyl)]-4-piperidinemethanol;[alpha,alpha-bis(p-fluorophenyl) ]-4-piperidinemethanol;[alpha,alpha-Bis(p-fluorophenyl)]-4-piperidinemethanol

Chemical Property of Bis(4-fluorophenyl)(piperidin-4-yl)methanol

Chemical Property:

• PSA: 32.26000
• LogP: 3.52910
• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 303.14347055
• Heavy Atom Count: 22
• Complexity: 321

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)O

Technology Process of Bis(4-fluorophenyl)(piperidin-4-yl)methanol

There total 6 articles about Bis(4-fluorophenyl)(piperidin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol (111627-25-9) → 1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol (60284-98-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 70 ℃; for 48h; under 2585.7 Torr;

DOI:10.1021/jm00121a022

Reference yield: 79.0%

→ 6-{3-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]propoxy}-7-methoxy-2H-1-benzopyran-2-one + 1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol (60284-98-2)

Guidance literature:

Reference yield: 38.2%

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) + 1-Bromo-4-fluorobenzene (460-00-4) → 1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol (60284-98-2)

Guidance literature:

1-Bromo-4-fluorobenzene; With iodine; magnesium; In tetrahydrofuran; at 10 - 45 ℃; for 0.5h;

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; In tetrahydrofuran; at 80 ℃; for 12h;

upstream raw materials:

α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

N-benzyl isonipecotic acid ethyl ester

1-Bromo-4-fluorobenzene

α,α-bis(4-fluorophenyl)-4-pyridinemethanol

Downstream raw materials:

1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride

AHR 5333

Bis-(4-fluoro-phenyl)-{1-[3-(2-phenyl-[1,3]dioxolan-2-yl)-propyl]-piperidin-4-yl}-methanol