5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid

Base Information

Chemical Name:5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid
CAS No.:1455090-10-4
Molecular Formula:C₂₆H₂₂FN₃O₅
Molecular Weight:475.476
Hs Code.:

Synonyms:5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid

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Chemical Property of 5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid

Chemical Property:

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Technology Process of 5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid

There total 8 articles about 5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455094-16-2
1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

: 660-88-8
5-aminopentanoic acid

: 1455090-10-4
5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid

Guidance literature:: With sodium methylate; In methanol; for 16h; Reflux;

Reference yield:

: 1455091-04-9
2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

: 1455090-10-4
5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

5: sodium methylate / methanol / 16 h / Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; caesium carbonate; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1455091-06-1
2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

: 1455090-10-4
5-{[1-(5-fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino}pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

4: sodium methylate / methanol / 16 h / Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; caesium carbonate; dibenzoyl peroxide; In methanol; tetrachloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;