(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Base Information

Chemical Name:(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
CAS No.:1398113-20-6
Molecular Formula:C₁₄H₁₂BrFN₂O
Molecular Weight:323.164
Hs Code.:

Synonyms:(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

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Chemical Property of (R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

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Technology Process of (R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

There total 10 articles about (R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398113-19-3
C₁₆H₁₈BrFN₂O₂

: 1398113-20-6
(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: With sodium methylate; In methanol; at 60 ℃; for 18h;

Reference yield:

: methyl (R)-1-(2-amino-2-(5-bromo-2-fluorophenyl)propyl)-1H-pyrrole-2-carboxylate hydrochloride

: 1398113-20-6
(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: With sodium methylate; In methanol; at 60 ℃;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield:

: 1228571-14-9
(2R)-2-amino-2-(5-bromo-2-fluorophenyl)propan-1-ol

: 1398113-20-6
(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

2.2: 64 h / -40 - 20 °C / Inert atmosphere

3.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 2 h / 0 - 20 °C

4.1: caesium carbonate / acetonitrile / 0.5 h / 130 °C / Microwave irradiation

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: sodium methylate / methanol / 60 °C

With hydrogenchloride; ruthenium trichloride; sodium periodate; thionyl chloride; sodium methylate; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00181