(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

Base Information

Chemical Name:(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine
CAS No.:1398113-23-9
Molecular Formula:C₁₄H₁₅FN₄
Molecular Weight:258.298
Hs Code.:

Synonyms:(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

Suppliers and Price of (R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

There total 13 articles about (R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398113-22-8
C₁₄H₁₃BrFN₃

: 1398113-23-9
(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

Guidance literature:: C₁₄H₁₃BrFN₃; With Benzophenone imine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 1h;

With sodium hydrogencarbonate; at 20 ℃; for 2h;

Reference yield:

: C₂₇H₂₃FN₄

: 1398113-23-9
(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 1h;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield:

: 1398113-20-6
(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

: 1398113-23-9
(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 96 h / 20 °C

2.1: ammonia; ammonium chloride / ethanol / 120 h / 80 °C / sealed tube

3.1: sodium t-butanolate; Benzophenone imine / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 100 °C / Inert atmosphere

3.2: 1 h / 20 °C

3.3: 2 h / 20 °C

With Benzophenone imine; ammonia; ammonium chloride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; dichloromethane; toluene;