(R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide

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Chemical Name:(R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide
CAS No.:1398112-69-0
Molecular Formula:C₂₁H₁₇FN₆O
Molecular Weight:388.404
Hs Code.:

Synonyms:(R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide

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Chemical Property of (R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide

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Technology Process of (R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide

There total 16 articles about (R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1398113-23-9
(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine

: 53234-55-2
5-cyano-pyridine-2-carboxylic acid

: 1398112-69-0
(R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: 5-cyano-pyridine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 0.0833333h;

(R)-3-(5-amino-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-amine; In methanol; at 0 - 20 ℃; for 3h;

Reference yield:

: 1398113-20-6
(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

: 1398112-69-0
(R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 96 h / 20 °C

2.1: ammonia; ammonium chloride / ethanol / 120 h / 80 °C / sealed tube

3.1: sodium t-butanolate; Benzophenone imine / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 100 °C / Inert atmosphere

3.2: 1 h / 20 °C

3.3: 2 h / 20 °C

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

4.2: 3 h / 0 - 20 °C

With Benzophenone imine; ammonia; ammonium chloride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 1398113-21-7
(R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

: 1398112-69-0
(R)-N-(3-(1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia; ammonium chloride / ethanol / 120 h / 80 °C / sealed tube

2.1: sodium t-butanolate; Benzophenone imine / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 100 °C / Inert atmosphere

2.2: 1 h / 20 °C

2.3: 2 h / 20 °C

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

3.2: 3 h / 0 - 20 °C

With Benzophenone imine; ammonia; ammonium chloride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; ethanol; toluene;