(Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide

Base Information

• Chemical Name: (Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide
• CAS No.: 1342198-98-4
• Molecular Formula: C₂₇H₃₁N₃O₃
• Molecular Weight: 445.561

Synonyms:(Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide

Chemical Property of (Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide

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Technology Process of (Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide

There total 3 articles about (Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

O-2-tetrahydro-2H-pyranhydroxylamine (6723-30-4) + 1-(4-tert-butyl-benzoyl)-3-(naphthalen-1-yl)-thiourea (356078-04-1) → (Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide (1342198-98-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2011.08.074

Reference yield:

1-amino-naphthalene (134-32-7) → (Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide (1342198-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 2 h / 56 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetone;

DOI:10.1016/j.tetlet.2011.08.074

Reference yield:

p-tert-butyl benzoyl chloride (1710-98-1) → (Z)-4-(tert-butyl)-N-(N'-(naphthalen-1-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)carbamimidoyl)benzamide (1342198-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 2 h / 56 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetone;

DOI:10.1016/j.tetlet.2011.08.074

upstream raw materials:

O-2-tetrahydro-2H-pyranhydroxylamine

1-(4-tert-butyl-benzoyl)-3-(naphthalen-1-yl)-thiourea

1-amino-naphthalene

p-tert-butyl benzoyl chloride

Downstream raw materials:

5-(4-(tert-butyl)phenyl)-N-(naphthalen-1-yl)-1,2,4-oxadiazol-3-amine

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