3-Methoxy-2-(phenylmethoxy)phenylalanine ethyl ester

Base Information

Chemical Name:3-Methoxy-2-(phenylmethoxy)phenylalanine ethyl ester
CAS No.:603945-44-4
Molecular Formula:C₁₉H₂₃NO₄
Molecular Weight:329.396
Hs Code.:
DSSTox Substance ID:DTXSID201220841
Nikkaji Number:J3.529.090G

Synonyms:SCHEMBL18608129;DTXSID201220841;J3.529.090G;3-Methoxy-2-(phenylmethoxy)phenylalanine ethyl ester;2-Amino-3-[2-(benzyloxy)-3-methoxyphenyl]propanoic acid ethyl ester;603945-44-4

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Chemical Property of 3-Methoxy-2-(phenylmethoxy)phenylalanine ethyl ester

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:329.16270821
Heavy Atom Count:24
Complexity:370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(CC1=C(C(=CC=C1)OC)OCC2=CC=CC=C2)N

Technology Process of 3-Methoxy-2-(phenylmethoxy)phenylalanine ethyl ester

There total 4 articles about 3-Methoxy-2-(phenylmethoxy)phenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 603945-44-4
2-amino-3-(2-(benzyloxy)-3-methoxyphenyl)propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 2 h / 100 °C / Inert atmosphere

2: diethyl amine hydrochloride / toluene / 12 h / 130 °C / Inert atmosphere; Dean-Stark

3: sodium tetrahydroborate; silica gel / chloroform; isopropyl alcohol / 0 - 20 °C

4: zinc; acetic acid / 2 h / 60 - 65 °C

With sodium tetrahydroborate; diethyl amine hydrochloride; silica gel; potassium carbonate; acetic acid; zinc; In ethanol; chloroform; isopropyl alcohol; toluene;
DOI:10.1016/j.tet.2015.07.018

Reference yield:

: 100-39-0
benzyl bromide

: 603945-44-4
2-amino-3-(2-(benzyloxy)-3-methoxyphenyl)propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 2 h / 100 °C / Inert atmosphere

2: diethyl amine hydrochloride / toluene / 12 h / 130 °C / Inert atmosphere; Dean-Stark

3: sodium tetrahydroborate; silica gel / chloroform; isopropyl alcohol / 0 - 20 °C

4: zinc; acetic acid / 2 h / 60 - 65 °C

With sodium tetrahydroborate; diethyl amine hydrochloride; silica gel; potassium carbonate; acetic acid; zinc; In ethanol; chloroform; isopropyl alcohol; toluene;
DOI:10.1016/j.tet.2015.07.018

Reference yield:

: 2011-06-5
2-benzyloxy-3-methoxybenzaldehyde

: 603945-44-4
2-amino-3-(2-(benzyloxy)-3-methoxyphenyl)propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl amine hydrochloride / toluene / 12 h / 130 °C / Inert atmosphere; Dean-Stark

2: sodium tetrahydroborate; silica gel / chloroform; isopropyl alcohol / 0 - 20 °C

3: zinc; acetic acid / 2 h / 60 - 65 °C

With sodium tetrahydroborate; diethyl amine hydrochloride; silica gel; acetic acid; zinc; In chloroform; isopropyl alcohol; toluene;
DOI:10.1016/j.tet.2015.07.018