3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester

Base Information

Chemical Name:3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester
CAS No.:752242-66-3
Molecular Formula:C₂₄H₃₅NO₇SSi
Molecular Weight:509.696
Hs Code.:

Synonyms:3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester

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Chemical Property of 3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester

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Technology Process of 3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester

There total 4 articles about 3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 752242-65-2
3-(6-ethanesulfonylpyridin-3-yloxy)-5-hydroxybenzoic acid methyl ester

: 136918-07-5
(2R)-1[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-propanol

: 752242-66-3
3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 1h;

Reference yield:

: 752242-65-2
3-(6-ethanesulfonylpyridin-3-yloxy)-5-hydroxybenzoic acid methyl ester

: 1137917-19-1
C₁₀H₂₄O₄SSi

: 752242-66-3
3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester

Guidance literature:: With caesium carbonate; In 1,3-dimethyl-2-imidazolidinone; at 80 ℃; Large scale reaction;
DOI:10.1021/op200068c

Reference yield:

: 859536-33-7
5-chloro-2-ethanesulfonyl-pyridine

: 752242-66-3
3-((1S)-2-(t-butyldimethylsiloxy)-1-methylethoxy)-5-(6-ethanesulfonylpyridin-3-yloxy)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl acetamide / 20 - 50 °C / Inert atmosphere; Large scale reaction

1.2: 7 h / 95 - 100 °C / Inert atmosphere; Large scale reaction

2.1: caesium carbonate / 1,3-dimethyl-2-imidazolidinone / 80 °C / Large scale reaction

With potassium tert-butylate; caesium carbonate; In 1,3-dimethyl-2-imidazolidinone; N,N-dimethyl acetamide;
DOI:10.1021/op200068c