3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt

Base Information

• Chemical Name: 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt
• CAS No.: 1137916-97-2
• Molecular Formula: CH₄O₃S*C₂₁H₂₄N₄O₆S
• Molecular Weight: 556.618

Synonyms:3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt

Chemical Property of 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

MK-0941 >98% ^*data from reagent suppliers

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Technology Process of 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt

There total 10 articles about 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.3%

methanesulfonic acid (75-75-2,98527-29-8) + 0.5C6H12N2*C17H19NO7S (1137917-12-4) + methyl-1 amino-3 pyrazole (1904-31-0) → 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt (1137916-97-2)

Guidance literature:

0.5C₆H₁₂N₂*C₁₇H₁₉NO₇S; With hydrogenchloride; In tert-butyl methyl ether; water; Inert atmosphere;

methyl-1 amino-3 pyrazole; With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; acetonitrile; at 20 - 30 ℃; for 2h;

methanesulfonic acid;

Reference yield: 20.0%

methanesulfonic acid (75-75-2,98527-29-8) + bis[3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)benzoic acid] 1,4-diazabicyclo[2.2.2]octane salt (1137917-12-4) + methyl-1 amino-3 pyrazole (1904-31-0) → 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt (1137916-97-2)

Guidance literature:

bis[3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)benzoic acid] 1,4-diazabicyclo[2.2.2]octane salt; methyl-1 amino-3 pyrazole; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

methanesulfonic acid;

DOI:10.1021/op200068c

Reference yield:

5-chloro-2-ethanesulfonyl-pyridine (859536-33-7) → 3-(6-ethanesulfonylpyridin-3-yloxy)-5-((S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonic acid salt (1137916-97-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl acetamide / 20 - 50 °C / Inert atmosphere; Large scale reaction

1.2: 7 h / 95 - 100 °C / Inert atmosphere; Large scale reaction

2.1: caesium carbonate / 1,3-dimethyl-2-imidazolidinone / 80 °C / Large scale reaction

3.1: hydrogenchloride; water / water

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With hydrogenchloride; potassium tert-butylate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,3-dimethyl-2-imidazolidinone; N,N-dimethyl acetamide; water;

DOI:10.1021/op200068c

upstream raw materials:

methanesulfonic acid

0.5C₆H₁₂N₂*C₁₇H₁₉NO₇S

methyl-1 amino-3 pyrazole

C₂₇H₄₁NO₇SSi

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