2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile

Base Information

• Chemical Name: 2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile
• CAS No.: 1262838-32-3
• Molecular Formula: C₂₆H₄₀N₂O₃
• Molecular Weight: 428.615
• Mol file: 1262838-32-3.mol

Synonyms:2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile

Chemical Property of 2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile

There total 8 articles about 2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-(4-(3,5-bis(hexyloxy)benzyloxy)butylidene)propanedinitrile (1262838-31-2) → 2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile (1262838-32-3)

Guidance literature:

With sodium tetrahydroborate; In isopropyl alcohol; at 0 ℃; for 1h;

DOI:10.1246/cl.2010.1166

Reference yield:

1-bromo-hexane (111-25-1) → 2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile (1262838-32-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 13 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.2: 0 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: silver(l) oxide / dichloromethane / 24 h / 20 °C / Inert atmosphere

5.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere

6.1: aluminum oxide / toluene / 1 h / 20 °C

7.1: sodium tetrahydroborate / isopropyl alcohol / 1 h / 0 °C

With aluminum oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene; acetonitrile;

DOI:10.1246/cl.2010.1166

Reference yield:

4-(3,5-bis(hexyloxy)benzyloxy)-1-butanal (1262838-20-9) → 2-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)propanedinitrile (1262838-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum oxide / toluene / 1 h / 20 °C

2: sodium tetrahydroborate / isopropyl alcohol / 1 h / 0 °C

With aluminum oxide; sodium tetrahydroborate; In isopropyl alcohol; toluene;

DOI:10.1246/cl.2010.1166

upstream raw materials:

4-(3,5-bis(hexyloxy)benzyloxy)-1-butanol

4-(3,5-bis(hexyloxy)benzyloxy)-1-butanal

2-(4-(3,5-bis(hexyloxy)benzyloxy)butylidene)propanedinitrile

1-bromo-hexane

Downstream raw materials:

5-(4-(3,5-bis(hexyloxy)benzyloxy)butyl)-2,4,6-pyrimidinetriamine