1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione

Base Information

Chemical Name:1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione
CAS No.:127103-52-0
Molecular Formula:C₁₆H₂₀N₂O₆
Molecular Weight:336.345
Hs Code.:

Synonyms:1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione

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Chemical Property of 1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione

Chemical Property:

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Technology Process of 1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione

There total 2 articles about 1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3027-05-2
N,N'-diacetylpiperazin-2,5-dione

: 127103-52-0
1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / t-BuOK, t-BuOH / tetrahydrofuran / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 80 °C / 51714.8 Torr

With potassium tert-butylate; hydrogen; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ja00165a095

Reference yield:

: 82622-02-4
5-(benzyloxy)-2,4-dimethoxy-3-methylbenzaldehyde

: 127103-52-0
1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / t-BuOK, t-BuOH / tetrahydrofuran / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 80 °C / 51714.8 Torr

With potassium tert-butylate; hydrogen; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ja00165a095

Reference yield:

: 127103-52-0
1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione

: (1R,3S)-1-[(S)-1-Amino-2-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-ethyl]-3-hydroxymethyl-5,7-dimethoxy-2,6-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / CH₂Cl₂ / Heating

2: Et₃N, DMAP / CH₂Cl₂ / -15 °C

3: 1.) t-BuOK, t-BuOH, 2.) DBU / 1.) THF, -78 deg C, 2.) 0 deg C

5: 99 percent / H₂ / Raney Ni-W₂ / ethanol / 120 °C / 77572.2 Torr

6: 85 percent / NaBH₃CN, TFA / methanol / 23 °C

7: 1.) DMAP, 2.) NaBH₄ / 1.) DMF, 60 deg C, 2.) EtOH, 0 deg C

8: TFA / 23 °C

With dmap; sodium tetrahydroborate; potassium tert-butylate; hydrogen; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; tert-butyl alcohol; Raney Ni-W₂; In methanol; ethanol; dichloromethane;
DOI:10.1021/ja00165a095